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"Promoters are important in determining when specific genes are turned on and off," says Feigin, "and I became interested in figuring out whether mutations within promoters -- as opposed to within the genes they regulate -consistently affects the way cancers develop and sustain themselves." The team "looked all across the genome," Feigin says, "and, interestingly, while we did find mutations in promoters, we never found clusters of these mutations near any of the genes that prior research had already told us were typically mutated in pancreatic cancer." Genes called KRAS and p53 are mutated in the majority of pancreas cancer cells, for example.

But mutations in promoters sifted out of mountains of data by the team's novel mathematical formula, or algorithm, called GECCO, lay in genes never before implicated in pancreatic cancer.

- holgentech_at_gmail_dot_com) Big Pharma & Big IT might lead together Genome Business by means of Genome Editing to cure cancers (Facebook note by Andras Pellionisz) Once upon a time, there was the Axiom that "Atoms Do Not Split”.

When they did, nuclear technology emerged prompted by the fact that fission (or fusion) releases unheard amounts of energy. First, however, quantum physics had to be developed to understand and thus control the process.

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