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Posted by / 17-Jan-2018 04:05

Consolidating p19

[...] High linkage disequilibrium can come either from an isolated population (for example, an island whose residents are all descendents of shipwreck survivors) or the relatively recent mixture of separate populations.

Bray and his colleagues did find evidence of elevated linkage disequilibrium in the Ashkenazi Jewish population, but were able to show that this matches signs of interbreeding or 'admixture' between Middle Eastern and European populations.

Our analysis indeed revealed higher European admixture than predicted from previous Y-chromosome analyses.

[...]" Gil Atzmon, Li Hao, Itsik Pe'er, Christopher Velez, Alexander Pearlman, Pier Francesco Palamara, Bernice Morrow, Eitan Friedman, Carole Oddoux, Edward Burns, Harry Ostrer.Excerpts: "Different communities of Jews around the world share more than just religious or cultural practices -- they also have strong genetic commonalities, according to the largest genetic analysis of Jewish people to date.But the study also found strong genetic ties to non-Jewish groups, with the closest genetic neighbours on the European side being Italians, and on the Middle Eastern side the Druze, Bedouin and Palestinians.Here, genome-wide analysis of seven Jewish groups (Iranian, Iraqi, Syrian, Italian, Turkish, Greek, and Ashkenazi) and comparison with non-Jewish groups demonstrated distinctive Jewish population clusters, each with shared Middle Eastern ancestry, proximity to contemporary Middle Eastern populations, and variable degrees of European and North African admixture.Two major groups were identified by principal component, phylogenetic, and identity by descent (IBD) analysis: Middle Eastern Jews and European/Syrian Jews.

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In addition, analyses of disease-related genes of higher prevalence in the Ashkenazi Jewish population indicate that only a minority of traits show signs of positive selection, suggesting that most have arisen through random genetic drift.